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Alternative approaches to consider Before committing to an untested combination, researchers should consider whether simpler approaches might achieve similar goals with known safety profiles

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Exendin-4 (Ex-4), another GLP-1RA that is homologous to commercially available exenatide, ameliorated IR in primary neurons through insulin receptor substrate-1 (IRS-1), AKT, and glycogen synthase kinase-3 (GSK-3) pathways

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